Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute

The goal of this project is to elucidate the molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease (NPC). We will investigate the role of protease BACE1, the key Alzheimer's disease (AD) enzyme, in the pathogenesis of NPC disease. We hope that our findings will elucidate BACE1 as a novel target for treating/ameliorating NPC disease.

Our research - Ruđer Bošković Institute

Silva Katusic Hecimovic - Senior Scientist - Ruđer Bošković

Niemann-Pick-C desease - CERMO-FC

Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C

Marko Košiček - Science communication coordinator - Ruđer Bošković

Converging pathways in neurodegeneration, from genetics to

PDF) Impaired Retromer Function in Niemann-Pick Type C Disease Is

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PDF) Overlapping Neuroimmune Mechanisms and Therapeutic Targets in

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