The role played by alternative splicing in antigenic variability in
Por um escritor misterioso
Last updated 29 setembro 2024
Endo-parasites that affect humans include Plasmodium, the causative agent of malaria, which remains one of the leading causes of death in human beings. Despite decades of research, vaccines to this and other endo-parasites remain elusive. This is in part due to the hyper-variability of the parasites surface proteins. Generally these surface proteins are encoded by a large family of genes, with only one being dominantly expressed at certain life stages. Another layer of complexity can be introduced through the alternative splicing of these surface proteins. The resulting isoforms may differ from each other with regard to cell localisation, substrate affinities and functions. They may even differ in structure to the extent that they are no longer recognised by the host’s immune system. In many cases this leads to changes in the N terminus of these proteins. The geographical localisation of endo-parasitic infections around the tropics and the highest incidences of HIV-1 infection in the same areas, adds a further layer of complexity as parasitic infections affect the host immune system resulting in higher HIV infection rates, faster disease progression, and an increase in the severity of infections and complications in HIV diagnosis. This review discusses some examples of parasite surface proteins that are alternatively spliced in trypanosomes, Plasmodium and the parasitic worm Schistosoma as well as what role alternate splicing may play in the interaction between HIV and these endo-parasites.
Genes, Free Full-Text
Alternative Splicing: New Insights from Global Analyses: Cell
The role played by alternative splicing in antigenic variability
Aire‐dependent transcripts escape Raver2‐induced splice‐event
Comprehensive Analysis of Alternative Splicing Across Tumors from
An unexplored angle: T cell antigen discoveries reveal a marginal
The relevance of alternative RNA splicing to pharmacogenomics
Immunoglobulin germline gene variation and its impact on human
Types of viral and mammalian alternative RNA splicing. Examples of
Cancers, Free Full-Text
Alternative splicing in aging and longevity
The role of alternative splicing in cancer: From oncogenesis to
Alternative splicing - Wikipedia
The role played by alternative splicing in antigenic variability
Recomendado para você
-
curl 7.77.0 regression: segfault in Curl_ssl_getsessionid29 setembro 2024
-
old edit // scp: zoylaep.scp #raisokolov #kylehunter #throneduet29 setembro 2024
-
The Rare Breed 1995 Vintage VHS Tape Vcr Classic Video James29 setembro 2024
-
Vietnam National Action Plan on SCP (2021-2030) ›29 setembro 2024
-
MariborFC29 setembro 2024
-
New 30-40cm Anime Scp Siren Head Plush Doll Toys Foundation Scary29 setembro 2024
-
PDF) Biological Characteristics of Verticillium dahliae MAT1-1 and29 setembro 2024
-
30.59% OFF on B2S ANITECH เครื่องบดสับอเนกประสงค์ รุ่น SCP300 สีดำ29 setembro 2024
-
4th of July Fireworks in Lake Mills - Enjoy Jefferson County29 setembro 2024
-
ArtStation - Woman Farmer29 setembro 2024
você pode gostar
-
Saiba quais são os jogos de hoje, sábado, 17 de junho, no Brasil e exterior29 setembro 2024
-
Vegeta (Canon, Dragon Ball Super Manga)/Vsdebaterman, Character Stats and Profiles Wiki29 setembro 2024
-
8 3/4 ORISHA ELLUGUA God Travelers Yoruba African Statue Antique Bronze Color29 setembro 2024
-
Gran Turismo 7 Update 1.36 Patch Notes: New cars, Menu Books, Scapes, Engine Swaps & more29 setembro 2024
-
Donut County Free Download » STEAMUNLOCKED29 setembro 2024
-
Carved Pumpkins, Smiling, on a Table Out of Doors Facing and Side29 setembro 2024
-
Gold Coast Theme Parks29 setembro 2024
-
BEAR* Comic Studio - make comics & memes with BEAR* characters29 setembro 2024
-
Stranger Things” Star Noah Schnapp Confirmed Will Is Gay and in Love with Mike29 setembro 2024
-
Kwai - download & share video on the App Store29 setembro 2024