Methodology of the DCCSS later fatigue study: a model to

Background A debilitating late effect for childhood cancer survivors (CCS) is cancer-related fatigue (CRF). Little is known about the prevalence and risk factors of fatigue in this population. Here we describe the methodology of the Dutch Childhood Cancer Survivor Late Effect Study on fatigue (DCCSS LATER fatigue study). The aim of the DCCSS LATER fatigue study is to examine the prevalence of and factors associated with CRF, proposing a model which discerns predisposing, triggering, maintaining and moderating factors. Triggering factors are related to the cancer diagnosis and treatment during childhood and are thought to trigger fatigue symptoms. Maintaining factors are daily life- and psychosocial factors which may perpetuate fatigue once triggered. Moderating factors might influence the way fatigue symptoms express in individuals. Predisposing factors already existed before the diagnosis, such as genetic factors, and are thought to increase the vulnerability to develop fatigue. Methodology of the participant inclusion, data collection and planned analyses of the DCCSS LATER fatigue study are presented. Results Data of 1955 CCS and 455 siblings was collected. Analysis of the data is planned and we aim to start reporting the first results in 2022. Conclusion The DCCSS LATER fatigue study will provide information on the epidemiology of CRF and investigate the role of a broad range of associated factors in CCS. Insight in associated factors for fatigue in survivors experiencing severe and persistent fatigue may help identify individuals at risk for developing CRF and may aid in the development of interventions.

Flowchart inclusion of CCSs and siblings of CCSs. CCS indicates

Overview of studies on the influence of genetic variation on

PDF) Methodology of the DCCSS later fatigue study: a model to

Fatigue in Healthy and Diseased Individuals - Josef Finsterer

Late Effects of Treatment for Childhood Cancer (PDQ®) - NCI

Adjusted model showing CF-associated factors in CCS. Figure shows

Hypothesized multivariable CRF model in CCS. Model showing

Methodology of the Dccss Later Fatigue Study: A Model to

Prevalence and risk factors of cancer‐related fatigue in childhood

PDF) Reliability and Validity of Turkish Versions of the Child