GPC2-CAR T cells tuned for low antigen density mediate potent

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…

GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma

Antigen density quantification of cell-surface immunotherapy targets by flow cytometry: Multi-antigen assay of neuroblastoma bone marrow metastasis - ScienceDirect

JCI - An optimized bicistronic chimeric antigen receptor against GPC2 or CD276 overcomes heterogeneous expression in neuroblastoma

Full article: B7-H3-targeted CAR-T cell therapy for solid tumors

Adoptive cell therapy in paediatric extracranial solid tumours: current approaches and future challenges - ScienceDirect

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

Frontiers Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

JCM, Free Full-Text

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models, Journal of Experimental & Clinical Cancer Research