Temozolomide (NSC 362856), DNA Alkylator

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.

Temozolomide nano enabled medicine: promises made by the nanocarriers in glioblastoma therapy - ScienceDirect

Biomedicines, Free Full-Text

Where to Buy 85622-93-1

Temozolomide American Journal of Cancer

Temozolomide (NSC 362856), DNA Alkylator

PDF] Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea.

Role of Temozolomide in the Treatment of Cancers Involving the Central Nervous System

Temozolomide resistance in glioblastoma multiforme. - Abstract - Europe PMC

Biomedicines, Free Full-Text

DNA/RNA合成阻害 DNA/RNA Synthesis Inhibition

Polymer–Temozolomide Conjugates as Therapeutics for Treating Glioblastoma

Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules