Genes that Escape Silencing on the Second X Chromosome May Drive Disease

When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.

Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control

Chromatin environment and CTCF enrichment predispose gene silencing and

B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells - ScienceDirect

The Xist repeat E deletion alters escape gene expression but not affect

Genes that escape from X‐chromosome inactivation: Potential contributors to Klinefelter syndrome - Navarro‐Cobos - 2020 - American Journal of Medical Genetics Part C: Seminars in Medical Genetics - Wiley Online Library

Live imaging of X chromosome inactivation and reactivation dynamics - Kobayashi - 2017 - Development, Growth & Differentiation - Wiley Online Library

The human inactive X chromosome modulates expression of the active X chromosome - ScienceDirect

The study of X-linked tumor suppressor genes challenges the two-hit

Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution

Gene regulation in time and space during X-chromosome inactivation

Abnormal X chromosome inactivation and tumor development

Biomedicines, Free Full-Text

Frontiers Escape From X-Chromosome Inactivation: An Evolutionary Perspective

A schematic diagram of contribution of escape genes to the female bias

Chromosome Xp - an overview