Relative Selectivity of Covalent Inhibitors Requires Assessment of Inactivation Kinetics and Cellular Occupancy: A Case Study of Ibrutinib and Acalabrutinib
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Last updated 26 dezembro 2024
Pharmaceuticals, Free Full-Text
Relative Selectivity of Covalent Inhibitors Requires Assessment of Inactivation Kinetics and Cellular Occupancy: A Case Study of Ibrutinib and Acalabrutinib
Development of covalent inhibitors: Principle, design, and application in cancer - Zheng - 2023 - MedComm – Oncology - Wiley Online Library
Proteomics and Beyond: Cell Decision-Making Shaped by Reactive Electrophiles: Trends in Biochemical Sciences
Deciding between one-step and two-step irreversible inhibition mechanisms on the basis of “kobs” data: A statistical approach
A Perspective on the Kinetics of Covalent and Irreversible Inhibition
Case Study - COVALfinder to Study Irreversible EGFR Drugs
Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen
Targeting Bruton tyrosine kinase using non-covalent inhibitors in B cell malignancies, Journal of Hematology & Oncology
Covalent Modifiers: 2017
PDF] Relative Selectivity of Covalent Inhibitors Requires Assessment of Inactivation Kinetics and Cellular Occupancy: A Case Study of Ibrutinib and Acalabrutinib
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