Pharmaceutics, Free Full-Text

Chronic wound healing represents an impactful financial burden on healthcare systems. In this context, the use of natural products as an alternative therapy reduces costs and maintains effectiveness. Phytotherapeutic gels applied in photodynamic therapy (PDT) have been developed to act as topical healing medicines and antibiotics. The bioactive system is composed of Spirulina sp. (source of chlorophylls) and Copaifera reticulata oil microdroplets, both incorporated into a polymeric blend constituted by kappa-carrageenan (k-car) and F127 copolymer, constituting a system in which all components are bioactive agents. The flow behavior and viscoelasticity of the formulations were investigated. The photodynamic activity was accessed from studies of the inactivation of Staphylococcus aureus bacteria, the main pathogen of hospital relevance. Furthermore, in vivo studies were conducted using eighteen rabbits with dermatitis (grade III and IV) in both paws. The gels showed significant antibiotic potential in vitro, eliminating up to 100% of S. aureus colonies in the presence or absence of light. The k-car reduced 41% of the viable cells; however, its benefits were enhanced by adding chlorophyll and copaiba oil. The animals treated with the phytotherapeutic medicine showed a reduction in lesion size, with healing and re-epithelialization verified in the histological analyses. The animals submitted to PDT displayed noticeable improvement, indicating this therapy’s viability for ulcerative and infected wounds. This behavior was not observed in the iodine control treatment, which worsened the animals’ condition. Therefore, gel formulations were a viable alternative for future pharmaceutical applications, aiming at topical healing.

MedLine Pharmaceutical

Pharmaceutics, Free Full-Text

PDF) Pharmacy and the EU : the impact of European Union membership on the pharmacy profession in Malta

Ashdin Publishing journals on LinkedIn: #articles #pharmaceutical #medical #science #viral #authors #trending…

Dota 6.64 Ai Plus - Colaboratory

UCC Pharmacy School on X: Delighted to announce our upcoming Pharmaceutical Quality and Regulatory Science Symposium on December 5th @Pharmacy_UCC. A really exciting line-up of speakers to be confirmed! Full details and

Pharmaceutics, Free Full-Text

Nitric Oxide Foundation - Berkeley Life Professional

Overcoming Barriers to Pharma Market Access in Emerging Markets, Request a FREE Proposal From Infiniti's Pharma Industry Experts for Detailed Insights

Identification of amino acid residues responsible for the release of free drug from an antibody-drug

Understanding Pharma: The Professional's Guide to How Pharmaceutical and Biotech Companies Really Work by John J. Campbell - Hardcover - 2008 - from Revaluation Books (SKU: __0976309637)

Colistin and polymyxin B: A re-emergence – topic of research paper in Clinical medicine. Download scholarly article PDF and read for free on CyberLeninka open science hub.

MXenes and MXene-based materials for removal of pharmaceutical compounds from wastewater: Critical review - ScienceDirect

PDF] BPR in the Pharmaceutical Industry

PDF) MEPHAS: an interactive graphical user interface for medical and pharmaceutical statistical analysis with R and Shiny