Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

Glial-mediated dysregulation of neurodevelopment in Fragile X

Structural and functional plasticity of dendritic spines – root or

Fragile X mental retardation protein controls ion channel

Biomolecules, Free Full-Text

Fragile X mental retardation protein in intrahepatic

mRNA Localization: An Orchestration of Assembly, Traffic and

Aberrant RNA translation in fragile X syndrome: From FMRP

Pten heterozygosity restores neuronal morphology in fragile X

IJMS, Free Full-Text

Alzheimer's disease-related dysregulation of mRNA translation

Multifarious Functions of the Fragile X Mental Retardation Protein

Which Comes First in Fragile X Syndrome, Dendritic Spine