Hybrid Membranes Development Made by Chitosan and Calcium

Medicine seeks increasingly to treat problems related to bone regeneration and tissue in order to minimize surgical trauma and some bone diseases. The technology advancement in the biomaterials field allows develop materials that assist in reconstructive procedures of body parts and increase treatments improving the life quality of human beings. Due to the biodegradability, biocompatibility and biofunctionality characteristics, chitosan has attracted attention of researchers in order to obtain new materials. Its unique features promote the incorporation of other materials such as calcium phosphate ceramics which are used in this bone replacement and bone regeneration due to submit biocompatibility, bioactivity, osteoconductivity in addition to allowing the bone cells proliferation, collagen and proteins in their surfaces, thus allowing tissue regeneration. This study aimed to develop biodegradable chitosan membranes with 1%, 3% and 5% calcium phosphate for use in bone regeneration. The composites were prepared and Characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and angle contact wettability. The results indicates the composite formation and show an increased crystallinity in the chitosan membrane through the phosphate incorporation, besides confirming the composites hydrophilicity. Preliminary results indicates that the composite is a promising biomaterial.

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