IJMS, Free Full-Text
Por um escritor misterioso
Last updated 24 janeiro 2025
The human Transient Receptor Potential A1 (hTRPA1) ion channel, also known as the wasabi receptor, acts as a biosensor of various potentially harmful stimuli. It is activated by a wide range of chemicals, including the electrophilic compound N-methylmaleimide (NMM), but the mechanism of activation is not fully understood. Here, we used mass spectrometry to map and quantify the covalent labeling in hTRPA1 at three different concentrations of NMM. A functional truncated version of hTRPA1 (Δ1-688 hTRPA1), lacking the large N-terminal ankyrin repeat domain (ARD), was also assessed in the same way. In the full length hTRPA1, the labeling of different cysteines ranged from nil up to 95% already at the lowest concentration of NMM, suggesting large differences in reactivity of the thiols. Most important, the labeling of some cysteine residues increased while others decreased with the concentration of NMM, both in the full length and the truncated protein. These findings indicate a conformational switch of the proteins, possibly associated with activation or desensitization of the ion channel. In addition, several lysines in the transmembrane domain and the proximal N-terminal region were labeled by NMM, raising the possibility that lysines are also key targets for electrophilic activation of hTRPA1.
IJMS, Free Full-Text
Ijms Free Full Text Delayed Onset Of Age Dependent Changes In Ultrastructure Of Myocardial 116100
IJMS, Free Full-Text
ISSN 1422-0067 (Online), International journal of molecular sciences
Ijms Free Full Text Neural And Hormonal Basis Of 49680
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS, Free Full-Text
Ijms Free Full Text Interplay Of Auxin And Cytokinin In Lateral Root Development
IJMS, Free Full-Text
IJMS, Free Full-Text
Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm
Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm
IJMS, Free Full-Text
IJMS, Free Full-Text
Recomendado para você
-
a Fluorescence emission spectra of NMM (400 nM) / ONS (300 nM) / Ag(I)24 janeiro 2025
-
NMM!Sans skin update24 janeiro 2025
-
Mean voltage amplitudes of each participant's PMM minus PM, and NMM24 janeiro 2025
-
Solved 1. Which of the following is incorrect? (a) the24 janeiro 2025
-
What does NMM mean? - NMM Definitions24 janeiro 2025
-
N Male to N Male Cable Assembly with RG401 Cable24 janeiro 2025
-
NMM-square-logo - Hammersmith Broadway24 janeiro 2025
-
File:Moonlight Scene - Ships Saluting NMM NMMG BHC1074.jpg - Wikipedia24 janeiro 2025
-
How OWG Grew Its Azure Practice 10x and Found Power in Partnership with Nerdio - Nerdio24 janeiro 2025
-
New Mexico Medical Insurance Pool When no one else will help, we're here.24 janeiro 2025
você pode gostar
-
Um desenho de três crianças com bonecas coloridas.24 janeiro 2025
-
Anime DVD The King's Avatar 全职高手 Season 1+2 + Movie ENG SUB All Region24 janeiro 2025
-
82+ Desenhos Anime Para Colorir24 janeiro 2025
-
Jogo Incredible Ice Cream Inventor no Jogos 36024 janeiro 2025
-
30 Years in Bariatrics, Insights from Dr. Nowzaradan, My 600lb24 janeiro 2025
-
História Fnaf universe - asneiras e chimas - História escrita por24 janeiro 2025
-
Tanjiro Vs Rui - Dublado, By Elite Demon Slayer24 janeiro 2025
-
PaRappa The Rapper Anti-Piracy screen (FANMADE) by starfallzinthesky on DeviantArt24 janeiro 2025
-
Rei do Empate24 janeiro 2025
-
Aplicativo do Gmail: Como baixar o app para Android, iOS e PC24 janeiro 2025