Cells, Free Full-Text

The enteric nervous system (ENS) constitutes the largest part of the peripheral nervous system. In recent years, ENS development and its neurogenetic capacity in homeostasis and allostasishave gained increasing attention. Developmentally, the neural precursors of the ENS are mainly derived from vagal and sacral neural crest cell portions. Furthermore, Schwann cell precursors, as well as endodermal pancreatic progenitors, participate in ENS formation. Neural precursors enherite three subpopulations: a bipotent neuron-glia, a neuronal-fated and a glial-fated subpopulation. Typically, enteric neural precursors migrate along the entire bowel to the anal end, chemoattracted by glial cell-derived neurotrophic factor (GDNF) and endothelin 3 (EDN3) molecules. During migration, a fraction undergoes differentiation into neurons and glial cells. Differentiation is regulated by bone morphogenetic proteins (BMP), Hedgehog and Notch signalling. The fully formed adult ENS may react to injury and damage with neurogenesis and gliogenesis. Nevertheless, the origin of differentiating cells is currently under debate. Putative candidates are an embryonic-like enteric neural progenitor population, Schwann cell precursors and transdifferentiating glial cells. These cells can be isolated and propagated in culture as adult ENS progenitors and may be used for cell transplantation therapies for treating enteric aganglionosis in Chagas and Hirschsprung’s diseases.

Towards reproducible cell-free systems

IJMS, Free Full-Text

Labile coat: reason for noninfectious cell-free varicella-zoster virus in culture. - Abstract - Europe PMC

Serial Number Alcohol 120 1.9 6 - Colaboratory

Remote immune processes revealed by immune-derived circulating cell-free DNA

Scheme of cell free cloning using DMF. ( A ) The full length construct

Effect of calendar ageing on the cycle life of anode-free full-cells.

Nt Novo Cella Get File - Colaboratory

Cell-Free Protein Expression

Cell-free protein synthesis for producing 'difficult-to-express' proteins - ScienceDirect

Mol Imaging Radionucl Ther on X: The Role of a Bone SPECT/CT Scan in the Follow-up of a Solitary Bone Lesion in a Patient with Langerhans' Cell Histiocytosis You can see the

Cell-free biology: exploiting the interface between synthetic biology and synthetic chemistry - ScienceDirect